SRINAGAR: In a major breakthrough, a Kashmiri scientist along with a group of European scientists has discovered a new potential drug for the treatment of metastatic hypoxic cancers. The drug is currently in an advanced stage of further investigations post-animal trials.
Dr Musadir Nabi Peerzada (AIIMS)
Hailing from Muqami Shahwali in Kupwara’s Drugmulla belt, Dr Mudasir Nabi Peerzada led a team of eminent European scientists and co-workers to discover a new drug for the treatment of various metastatic hypoxic cancers.
Dr Peerzada who is currently working as a C-Level scientist at AIIMS New Delhi, has completed his postdoctoral training at the National Institute of Pathology. He was awarded a prestigious postdoctoral fellowship by the Indian Council of Medical Research (ICMR), Department of health research, Government of India.
The discovery is believed to help in silencing the HIF-1 factor-controlled human CAIX and CAXII activity in cancerous cells. The hCAIX and hCAXII are overexpressed in the renal, pancreatic, gut, oral, brain, lung, and ovarian cancers, therefore the drug could be significant in treating multiple cancers with greater efficacy.
Dr Mudasir said that he and his team strenuous efforts for many years to make this path-breaking discovery. The drug has shown satisfactory results in various tumour models and is currently undergoing advanced investigations.
“This discovery took us years of tests and trials. We tested it on animals before going ahead,” Dr Peerzada said, adding that the drug is undergoing advanced clinical trials for further investigation.
The study was published in ACS Medicinal Chemistry Letters entitled Discovery of Novel Hydroxyimine-Tethered Benzenesulfonamides as Potential Human Carbonic Anhydrase IX/XII Inhibitors was published on May 8, 2023.
He said that the new findings are remarkable in curing hypoxic cancers and will be a boon for cancer-related research.
The other scientists who are part of this invention include Dr Alessandro Bonardi, Dr Niccolò Paoletti, Dr Daniela Vullo, Dr Paola Gratteri, Dr Claudiu T Supuran, and Dr Amir Azam
Dr Peerzada is working on the development of anti-cancer therapeutics discovery taking into account the ATP binding site of kinases, hCAIX, hCAXII activity, cycle arrest at the G2/M phase of mitosis, prevention of HER2 dimerisation to deregulate PI3K/AKT and MAPK cell signalling pathways.
The website for the committee was changed on Tuesday morning to say that its mission is “committed to advancing the Freedom Agenda and keeping Florida free.” But more importantly, the website was changed to say that the committee is associated with state Sen. Blaise Ingoglia and not DeSantis. The committee on Tuesday also filed paperwork that said Ingoglia replaced a Tampa accountant as the official chair of the organization.
Ingoglia is a Republican ally of DeSantis who sponsored several of the governor’s key legislative priorities during the recently concluded legislative session, including a crackdown on illegal immigration that includes $12 million for the governor’s controversial migrant relocation program.
A spokesperson with DeSantis’ political operation did not comment on the shift and Ingoglia did not immediately respond to a request for comment.
DeSantis first set up his committee back in 2018 and he used it to raise a record amount of money for his re-election campaign last year as he pulled in donations from many major Republican donors. Current campaign finance records show that the committee has nearly $86 million in the bank.
But DeSantis cannot use money raised for Friends of Ron DeSantis in a federal race because state law does not limit how much someone can give to the political committee or the source of the donations. But that money could be shifted to a super PAC that backs DeSantis if the governor is no longer connected to the political committee. While some have questioned the legality of such a move, the Federal Elections Commission deadlocked over a similar strategy that was used by Rep. Byron Donalds (R-Fla.).
Ingoglia did not respond to a question about whether or not the political committee will shift money to a super PAC helping the governor’s bid for the White House.
This step comes as DeSantis ratchets up plans to start stumping for his White House bid.
After concluding a frenzied legislative session last week, the governor flew to the battleground state of Wisconsin — which former President Donald Trump won in 2016 and lost four years later — to make an appeal to the Marathon County GOP. On Saturday, he plans to hit the early voting state of Iowa to attend Rep. Randy Feenstra’s annual picnic. And next month he will head to Nevada, another early voting state, to headline an annual Basque fry event.
In the meantime, he has been hosting dinners with financial supporters at his official residence in Tallahassee, and trying to assure them he could win critical states like Georgia and Arizona, according to someone with knowledge who was granted anonymity to share details of the private discussions. And he recently dined with Evangelical leader Bob Vander Plaats, who runs the conservative Family Leader in Iowa.
He has also been fine-tuning his stump speech as he goes on the road — seeking to bolster his arguments against President Joe Biden while figuring out a way to differentiate himself from Trump without alienating the ex-president’s loyal base.
“Joe Biden has done more to damage this country in two and a half years than any president in our lifetime,” he said during his speech in Wisconsin.
But DeSantis avoided any mention of Trump — instead highlighting his own electoral success in Florida in an attempt to underscore the weak performance by candidates tied to the ex-president, a frustration for many Republicans. He previewed a few other potential attack lines against his chief primary rival, calling out Trump’s former top Covid-19 advisor, Anthony Fauci, whose early pandemic guidance DeSantis proudly bucked.
But in a recent Newsmax interview, DeSantis directly responded to Trump’s attacks on the governor’s past support of cuts to Medicare.
“Those are Democrat attacks. I don’t think anyone really buys that,” DeSantis said about ads Trump’s PAC is running. “Donald Trump himself wrote a book where he was talking about the need to increase the age of eligibility for Social Security to 70 and said people shouldn’t be worried about retiring, just keep working.”
Polling consistently shows DeSantis trailing Trump in the primary but competing well in a head-to-head contest with Biden.
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( With inputs from : www.politico.com )
SRINAGAR: Jammu and Kashmir Police on Sunday arrested a militant associate and recovered an Improvised Explosive Device(IED) from his disclosure in Pulwama district, officials said.
In a tweet, Kashmir Zone Police said that the arrested person was a resident of Arigam.
“Pulwama Police averted a major tragedy by apprehending a terror associate Ishfaq Ahmed Wani R/O Arigam Pulwama and recovering an IED (approx 5-6Kgs) on his disclosure. Case registered and investigation started,” it said.
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#Militant #Associate #Arrested #IED #Major #Tragedy #Averted #Police( With inputs from : kashmirlife.net )
Srinagar, May 07 : Jammu and Kashmir police on Sunday claimed to have averted major tragedy by arresting a militant associate along with 5 Kg Improvised Explosive Device in south Kashmir’s Pulwama district.
Kashmir zone police in a Tweet, as per the news agency—Kashmir News Observer (KNO) informed that based on the disclosure of apprehended militant associate 5-6 Kg IED was recovered, thereby a major tragedy was averted.
Police said a case has been registered in this regard and further investigation has been taken up.
“Pulwama Police averted a major tragedy by apprehending a #terror associate Ishfaq Ahmed Wani R/O Arigam #Pulwama and recovering an #IED (approx 5-6Kgs) on his disclosure. Case registered and investigation started,” police tweeted—(KNO)
SRINAGAR: Police in Kashmir have thwarted a major militant attack plot by arresting a militant associate of Jaish-e-Mohammad (JeM) who was working as a driver in a five-star hotel.
Farooq Ahmad Wani, son of Abdul Rashid Wani, was arrested from the hotel where he worked in Baramulla district last week. During the interrogation, police discovered that Wani was in contact with his handlers in Pakistan and had sent pictures and other details of some of the 5-star hotels in Kashmir where high-profile guests, including Union Ministers, top leaders, and senior officials stay.
The arrest comes ahead of the G20 group meeting in Srinagar from May 22 to May 24. The security has been tightened around the hotels in Srinagar and other places as there is a serious input about a possible militant strike in Kashmir. The police recovered a grenade from Wani’s possession, and he is being questioned, providing leads to the authorities.
The security review meeting in Srinagar was conducted by the Additional Director General of Police Kashmir, Vijay Kumar, focusing on the emerging threat of Vehicle-Based Improvised Explosive Devices (VBIEDs) and other potential modes of militant attacks, including Fidayeen.
The presence of a militant in a 5-star hotel and the audacious attack in Poonch last month on Army has led to elite Marine Commandos (MARCOS) and National Security Guards (NGS) being placed for the security of the G20 Group meeting in Srinagar. The official clarified that the hotel management had no knowledge of Wani’s militant links, and he had developed links several months after working in the hotel.
Srinagar, May 4: In a major breakthrough, police in Kashmir foiled a Jaish-e-Mohammad (JeM) plot of a major militant attack when they arrested a militant associate of the outfit who was working in a five-star hotel as a driver.
Police last week arrested Farooq Ahmad Wani son of Abdul Rashid Wani, resident of Wagoob Hygam, Baramulla district from a five start hotel in Kashmir where he was working as a driver.
A senior police official told Excelsior that during the interrogation it was found that he was in touch with his handlers across in Pakistan and had sent pictures and other details of some of the 5-star hotels of Kashmir where high profile guests including Union Ministers and other top leaders and senior officials stay.
The plot has been foiled ahead of G20 group meeting in Srinagar that is being held from May 22 to May 24 and the officer said that it is a major success.
A grenade was recovered from his possession and he is being questioned and police is working on the leads provided by him.
He said that the security has been further tightened around the hotels in Srinagar and other places ahead of the G20 meet as there is serious input about possible militant strike in Kashmir.
It may be mentioned here that only yesterday, Additional Director General of Police Kashmir, Vijay Kumar, took a security review meeting in Srinagar during which a special focus was laid on the emerging threat of Vehicle Based Improvised Explosive Devices (VBIEDs) and other modes of potential militant attacks including Fidayeen.
Sensing the gravity of the threat after audacious attack in Poonch last month on Army and the presence of a militant in 5-star hotel, elite Marine Commandos (MARCOS) and National Security Guards (NGS) are being placed for the security of G20 Group meeting in Srinagar.
The official said that the hotel management had no knowledge about the driver having militant links. He further said that Wani had developed links several months after working in the hotel.
SRINAGAR MAY 03:- The Deputy Commissioner(DC), Srinagar, Mohammad Aijaz Asad Wednesday undertook an extensive tour of City areas to inspect progress of various ongoing major projects being carried out at Government Women’s College M.A Road, Lal-Ded Maternity Hospital, Amar Singh College Gogji Bagh and beautification project along the Jhelum River embankments from Zero Bridge to LD Hospital under Srinagar Smart City initiative.
The DC also visited Central Veterinary Hospital Maisuma and took stock of its functioning.
At Government Women’s College M.A Road, the Deputy Commissioner inspected the under construction Administrative Block being constructed at an estimated cost of Rs 5.63 crore.
On the occasion, the DC expressed his displeasure over the slow pace of the work. He directed the concerned executing agency to speed up the pace of work by employing additional men and machinery. The DC sets July, 2023 deadline for the completion of the project.
The DC also visited the construction site of a new 200-bedded Extension Block/Gynaecology & Infertility Block of Lal Ded (LD) Maternity Hospital being constructed at a cost of Rs 132 crore.
While inspecting the progress of works of the project, the DC was apprised about the physical status of the under construction project. He was informed that the five-floor building will have a complete Oncology Department, High End Labour Room, and 4 Operation Theatres and a big Diagnostic Laboratory and Neonatal Unit. In addition, there will be a ground plus 5-floors with parking space, patients waiting lounge, canteen, new-born section, and hospital equipment and also space for wards.
The DC was also informed that work on the project will pick up the pace as soon as base isolators are procured.
Hundreds of civilians on Sunday fled Ukrainian territories under Russian control as part of an “evacuation” ahead of what’s feared to be intense fighting around an area home to Europe’s largest nuclear power plant.
A Ukrainian mayor slammed Moscow’s move as a cover-up operation to move troops, while the U.N. nuclear watchdog raised concerns over heavy fighting during a potential spring counteroffensive when Ukrainian forces are expected to seek to regain control of territories lost to Russian control.
Russian forces announced the evacuation for 18 settlements on Friday, and over the weekend, civilians have been rushing to leave those areas. The Ukrainian mayor of Melitopol, Ivan Fedorov, called it a “mad panic” as thousands of cars were stuck on the roads with five-hour waits, BBC reported.
Meanwhile, Russian paramilitary group Wagner’s boss on Sunday signaled that his men would continue to fight in the Ukrainian city of Bakhmut, a U-turn from an earlier threat — made in a video filmed alongside dead bodies — to withdraw from there as he criticized Moscow for failing to supply his group with the ammunition it needed.
Russian defense officials reportedly had reservations about over-assisting Yevgeny Prigozhin, whose Wagner mercenaries have played a key role in securing control over Ukraine’s eastern territories.
In Bakhmut, Ukraine has accused Russia of attacking the besieged city with phosphorus munitions.
Russia’s Federal Security Services claimed on Sunday they had foiled an attempt by Ukrainian intelligence to attack a military airfield in central Russia with drones stuffed with explosives. Kyiv has not responded to the accusation but previously attributed such actions to “false flag” operations or Russians opposed to President Vladimir Putin.
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( With inputs from : www.politico.eu )
“People who you’ve read about or know about – there they are looking right at you.” Art curator Kara Vander Weg is talking with me about global art gallery Gagosian’s major new Richard Avedon retrospective, in which 150 individuals – ranging from the younger Barbara Bush to Khloé Kardashian to Spike Lee to Elton John to Renata Adler to Vander Weg herself – each selected a single Avedon photo to celebrate. She’s explaining the intimacy that she believes sets Avedon’s photos apart. “His subjects are looking right at you, and you can look right at them. You can’t help but react to the human right there in front of you.”
Avedon was monumental for the size of his photos, which tended to be printed in life-size or larger, leading to the effect that Vanger Weg described, where viewers can look right at his subjects and have an encounter that feels extremely intimate. “It’s a really interesting relationship between art and the viewer,” she told me. “Avedon must have known. He would work for months and months with models trying to find the right sizes of images. He must of known that humans in the room would relate to the images in a really special way. That’s what it is about these photographs, you’re looking in the eyes of another person. You can’t help but connect.”
In addition to being monumental for his size, Avedon was also monumental for his range – from heads of state to celebrities to art creators, fashion models, writers, musicians and even a beekeeper, his output feels almost impossibly capacious. “He spanned so many different genres,” said Derek Blasberg, another curator with Gasgosian who has been integral in putting together Avedon 100. “He shot almost every important figure of the second half of the 20th century.”
Showing from 4 May through 24 June, Avedon 100 will dominate Gagosian’s gallery space in New York’s Chelsea district. The show does feel enormous, with showstoppers from one area after another, be it politics, fashion, film, literature, street scenes, music. “What is awesome about this show is that it’s an enormous look at all of Avedon,” said Blasberg. “It spans from the earliest days of him touching a camera.” That includes what Blasberg deemed “arguably the first mirror selfie”, a side-by-side photo Avedon made with author James Baldwin. The 1946 image definitely has the aesthetics of a selfie, with Baldwin smiling into the mirror, eyes pointed toward the lens, while Avedon squints down into the viewfinder, his camera looking eerily like an iPhone.
Richard Avedon and James Baldwin, Harlem, New York, 1946 Photograph: Richard Avedon/Photograph(s) by Richard Avedon. The Richard Avedon Foundation
From the small to the large, the show also features two gigantic murals – one of Andy Warhol posing with members of The Factory (10ft high by 31ft wide) and one of poet Allen Ginsberg with members of his extended family (9ft by 20ft). “The two large murals are a tour de force,” said Vander Weg. “They were printed before any kind of digital printing, so it was a massive job to get them done correctly.” Indeed, these murals are among the largest fine art photos ever printed, and in their time they pushed the boundaries of what was possible with the photographic medium.
Vander Weg went on to explain that Gagosian “had a specific day dedicated to just installing those two murals. They were brought in rolled up, and then they were unrolled under supervision”. During Avedon’s lifetime the murals would not have been exhibited under glass, but since the photographer’s death in 2004 they have grown immeasurably more precious, and now glass is required. That’s because, according to Vander Weg, Avedon’s will contained a clause against printing any more of his photos. In addition, the Avedon Foundation, which now authenticates and licenses all of the photographer’s work, is known to go after anyone attempting to sell unauthenticated Avedon prints. “Collectors like knowing that there’s a finite body of work,” said Vander Weg. “Each one is signed and stamped on the back, making them precious objects.”
Cindy Crawford for Versace, hair by Yannick D’Is, makeup by François Nars, New York, 1994 Photograph: Photograph(s) by Richard Avedon. The Richard Avedon Foundation
Many of the individuals invited to help curate the show – particularly those from the fashion world – ended up selecting images of themselves. There’s Tom Ford looking gregarious and confident – the fashion designer said he adored the image so much that he ended up using it on the back cover of his first book. Supermodel Naomi Campbell chose a full-body, naked shot of herself encrusted with sand, a powerful, intent stare on her face. Quintessential supermodel Cindy Crawford chose a nine-exposure series that captured her flinging her hair around, looks of playful rapture beaming from her face. And Stephanie Seymour picked a shot of her in a sheer dress in a pose reminiscent of a ballet dancer, her pregnant belly clearly visible.
“Seymour said that working with Avedon was like a graduate program in modeling,” said Blasberg. “It was awesome to hear models talk what it was like to work with him. Linda Evangelista said that nobody did lighting like him.”
Although Avedon 100 certainly offers plenty of opportunities to view the powerful and the famous, Vander Weg also noted that many of the photographs involve anonymous or unknown individuals. For the image she curated, she picked one of a young boy, from an unpublished series for Life magazine done in 1949. “What’s really interesting about the whole series is that they’re not known sitters. They’re just everyday people, not posing. Yet he manages to give them all a dignity and a glamorous presentation. He knew so well how to frame, what would make them look their best. I look at that boy and think about the determination of many people who come to New York City. I really connect to it. You look at the eyes, and you think ‘this kid is going somewhere.’”
Richard Avedon. Photograph: Eamonn McCabe/The Guardian
In an intimate, fun touch, each image comes with a brief text composed by the curator, where they offer often personal stories explaining why they chose what they did. Blasberg shared with me that he chose the Warhol Factory mural because, as a kid growing up in St Louis, it made him realize there was so much more to the world. “I remember the first time I saw that image, I was so struck by it. Over the years I’ve dived more and more into what was behind that photo. For a little boy from Missouri to see a glorification of male beauty – it made me think I have to get to New York. I wanted to be one of those cool kids in that shop.” Decades later and an art world insider, Blasberg finds “working on this show has been a total surreal career highlight.”
Avedon 100 feels like a one-of-a-kind event because it’s such a large-scale show, bringing together so many strands of an enormous career. It’s a fitting testament to a major American creator. In the words of Vander Weg, “People have grown up seeing these images, but to see them in a room all together is something else. One man’s incredibly interesting, varied life – it will be a very powerful experience.”
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( With inputs from : www.theguardian.com )
Carlson’s last program was Friday. “Fox News Tonight” will air at 8 p.m. EST — previously the slot for “Tucker Carlson Tonight” — starting Monday as an “interim show helmed by rotating FOX News personalities until a new host is named.”
Lemon was fiery in his response to being ousted, stating on Twitter that he was “stunned” that he had been terminated by the network.
“At no time was I ever given any indication that I would not be able to continue to do the work I have loved at the network. It is clear that there are some larger issues at play,” he wrote.
Though, CNN, in a tweet said Lemon’s statement is “inaccurate” and that he was “offered an opportunity to meet with management but instead released a statement on Twitter.”
The exits come ahead of the White House Correspondents’ Dinner, slated for Saturday. The annual event, attended for decades by presidents from both parties, celebrates the First Amendment and honors journalists. The headliner usually takes the stage to deliver the traditional WHCA dinner roast. This year’s headliner, Roy Wood Jr., said he already threw out his script following the exits of Lemon and Carlson.
Both anchors have faced their fair share of controversy in recent months leading up to their departures on Monday.
Lemon, who had worked at CNN for 17 years, said on-air in February that presidential hopeful Nikki Haley “isn’t in her prime” and that a woman is “in her prime in her 20s, 30s, 40s.” He later apologized for the comments on Twitter and didn’t appear on “CNN This Morning” the next day.
Earlier this month, Variety published a report claiming that Lemon made other offensive comments about women on air in the past and alleged inappropriate behavior toward female colleagues at CNN.
News of Carlson’s departure came the week after Fox News settled Dominion Voting Systems’ defamation lawsuit for $787.5 million. Carlson, along with hosts Sean Hannity and Laura Ingraham, privately mocked regular guests such as Donald Trump’s attorneys, Rudy Giuliani and Sidney Powell, while continuing to promote conspiracy theories to their audience.
Last month, the White House joined in widespread condemnation of Carlson, singling him out for his misleading portrayal of the U.S. Capitol riot on Jan. 6, 2021. The revelations were made public as part of the lawsuit by Dominion.
Former “Tucker Carlson Tonight” producer Abby Grossberg is also suing the network after stating that she was unlawfully fired as an act of retaliation.
Carlson first joined Fox News as a contributor in 2009, and in 2017, Carlson took over the network’s 8 p.m. hour after Bill O’Reilly was forced out. Carlson was one of the most-watched hosts on the cable news network, with an average audience of 3.2 million viewers.
On Monday morning, Fox News had still been previewing Carlson’s show, teasing an interview with presidential hopeful Vivek Ramaswamy that would air Monday night.
Fox News anchor Harris Faulkner addressed Tucker Carlson’s departure Monday by stating, “We have some news from within our Fox family. Fox News Media and Tucker Carlson have mutually agreed to part ways.”
Politicians as well as former and current TV hosts were quick to react to the news of the exits.
Former Fox News anchor Megyn Kelly, who left the network in 2017, said the news was “Good for Tucker.”
Fox host Sean Hannity posted to Twitter, “*LATER LEMON!*” but did not address Carlson’s departure.
“Good News: “The dumbest man on television,’ Don Lemon, has finally been fired from Fake News CNN,” former President Donald Trump said on Truth Social. “My only question is, WHAT TOOK THEM SO LONG?” Trump posted on Truth Social.
And in a tweet, Russian-backed English-language news outlet RT News appeared to offer Carlson a job.
