Thane: Police have arrested four persons and seized from them bottles of cough syrup containing codeine, a banned narcotic drug, worth Rs 9.30 lakh in Thane district of Maharashtra, an official said on Sunday.
The action was taken on Friday evening at Kontari village in Bhiwandi taluka of the district, he said. “Acting on a tip-off, a team of Kongaon police station raided a place and found that a consignment of cough syrup being transferred from a truck into a tempo.
The police seized the goods worth Rs 9.30 lakh and arrested four persons,” Assistant Commissioner of Police (Bhiwandi) Kishore Khairnar said.
The police also seized two vehicles – a truck and a tempo – collectively worth Rs 8.50 lakh, the official added.
An offence under relevant sections of the Indian Penal Code (IPC) and the Drugs and Cosmetics Act was registered against the arrested accused, he said.
New Delhi: India’s drug regulator has directed drug manufacturers not to use propylene glycol supplied by a Delhi-based company which provided the ingredient to Marion Biotech, whose cough syrups were alleged to have led to the deaths of children in Uzbekistan.
Maya Chemtech India Pvt. Ltd. supplied propylene glycol used in Marion Biotech’s cough syrups that were found to be “not of standard quality”, according to the regulator.
Three employees of Marion Biotech were arrested on charges of manufacture and sale of adulterated drugs.
Also, the drugs inspector from the Central Drugs Standard Control Organisation (CDSCO) North Zone last week issued a notice to the pharmaceutical firm asking it to stop the sale and distribution of the drug concerned, stating that the sample was found to be “not of standard quality”.
Uzbekistan alleged in December last year that several children died after consuming Marion Biotech’s cough syrups, which it claimed were contaminated with unacceptable amounts of ethylene glycol or propylene glycol.
According to a communication sent by Drug Controller General of India (DCGI) Rajeev Raghuvanshi to the licensing authorities of all states and Union territories on March 7, during the course of investigation a total of 33 samples were drawn by drugs inspectors. The test reports of 30 drug samples have been received, wherein 24 samples were declared as “not of standard quality”.
Also, out of these samples, 22 fall under the category of adulterated/spurious under Sections 17A and 178 of the Drugs and Cosmetics Act, 1940.
“It is further informed that M/s Maya Chemtech India Pvt. Ltd…was mainly the supplier of propylene glycol which has been used in the impugned batches. In view of the above, you are requested to issue directions to all manufacturers in your jurisdiction not to use propylene glycol supplied by Maya Chemtech India Pvt,” the DCGI said in the letter.
Accordingly, he also requested them to instruct their enforcement officials to keep strict vigil on the matter and take stringent action as per law against the offenders in public interest.
On January 12, the World Health Organization (WHO) had issued a “medical product alert”, referring to two substandard (contaminated) products, identified in Uzbekistan and reported to it on December 22, 2022.
“The two products are AMBRONOL syrup and DOK-1 Max syrup. The stated manufacturer of both products is MARION BIOTECH PVT. LTD, (Uttar Pradesh, India). To date, the stated manufacturer has not provided guarantees to WHO on the safety and quality of these products,” the WHO had said then.
“Laboratory analysis of samples of both products, undertaken by national quality control laboratories of the Ministry of Health of the Republic of Uzbekistan found both products contained unacceptable amounts of diethylene glycol and/or ethylene glycol as contaminants,” it had noted.
New Delhi: A persistent cough, sometimes accompanied by fever, running through India for the past two-three months is due to Influenza A subtype H3N2, ICMR experts said.
The H3N2, which has been in wide circulation for the past two-three months, causes more hospitalisations than other subtypes, said Indian Council of Medical Research (ICMR) scientists who keep a close watch on ailments caused by respiratory viruses through the Virus Research and Diagnostic Laboratories network.
They have also suggested a list of Dos and Don’ts for people to follow to protect themselves from contracting the virus.
The Indian Medical Association (IMA), on the other hand, has advised against indiscriminate use of antibiotics amid rising cases of cough, cold and nausea across the country.
Seasonal fever will last five to seven days, it said.
The fever goes away at the end of three days but the cough can persist for up to three weeks, the IMA’s Standing Committee for Anti-Microbial Resistance said.
Viral cases have also surged due to air pollution, it said, adding that it mostly occurs in people aged below 15 and above 50 and causes upper respiratory infections along with fever.
The association also asked doctors to prescribe only symptomatic treatment and not antibiotics.
“Right now, people start taking antibiotics like Azithromycin and Amoxiclav etc, that too without caring for done and frequency and stop it once start feeling better. This needs to be stopped as it leads to antibiotic resistance. Whenever there will be a real use of antibiotics, they will not work due to the resistance,” the IMA said in a statement.
The most misused antibiotics are Amoxicillin, Norfloxacin, Oprofloxacin, Ofloxacin and Levofloxacin. These are being used for the treatment of diarrhoea and UTI, it said.
“We have already seen widespread use of Azithromycin and Ivermectin during Covid and this too has led to resistance. It is necessary to diagnose whether the infection is bacterial or not before prescribing antibiotics,” it said.
(Except for the headline, this story has not been edited by Siasat staff and is published from a syndicated feed.)
New Delhi: A joint probe by the Centers for Disease Control and Prevention (CDC) of the US and the Gambian health authorities have suggested a strong link between the death of many children in Gambia and the consumption of made-in-India cough syrups that were allegedly contaminated.
In October, the World Health Organization (WHO) had issued an alert stating that the four cough syrups being supplied to Gambia by the India-based Maiden Pharmaceuticals Ltd were of substandard quality and claimed that they were linked to the death of many children in Gambia.
A CDC report released on Friday stated, “This investigation strongly suggests that medications contaminated with Diethylene Glycol [DEG] or Ethylene Glycol [EG] imported into the Gambia led to this Acute Kidney Injury (AKI) cluster among children.”
“Patients with DEG poisoning can experience a range of signs and symptoms, including altered mental status, headache, and gastrointestinal symptoms; however, the most consistent manifestation is AKI, characterized by oliguria (low urine output) or anuria, progressing over 1-3 days to renal failure (indicated by elevated serum creatinine and blood urea nitrogen),” read the report.
According to the CDC, they were contacted by Gambia’s Ministry of Health (MoH) to assist in characterizing the illness (multiple cases of Acute Kidney Injury and deaths in children), describing the epidemiology, and identifying potential causal factors and their sources in August last year.
The report also said that in past DEG outbreaks, manufacturers have been suspected of substituting DEG in the place of more expensive, pharmaceutical-grade solvents.
“Among reports of AKI associated with DEG-contaminated medical products, this is the first in which DEG-contaminated medications were imported into a country, rather than being domestically manufactured,” it said.
It further said medications for export might be subject to less rigorous regulatory standards than those for domestic use.
“Simultaneously, low-resource countries might not have the human and financial resources to monitor and test imported drugs,” it stated.
Union Minister of State for Health Bharati Pravin Pawar in a reply to Lok Sabha on February 3 had said that after testing, the samples of the cough syrups have been declared to be of standard quality.
The samples were found to be negative for both Diethylene Glycol (DEG) and Ethylene Glycol (EG), Pawar had said in a written reply to a question.
Mumbai: The Maharashtra government told the state Legislative Assembly on Friday that the licenses of six manufacturers of cough syrups in the state have been suspended for not following the rules.
Food and Drugs Administration Minister Sanjay Rathod made the statement while replying to a calling attention notice by Ashish Shelar (BJP) and others.
Recently, a cough syrup made by a Noida-based firm was alleged to have caused the death of 18 children in Uzbekistan. Noida police on Friday said they had arrested three employees of the firm.
Rathod said that the Maharashtra government had initiated inquiry against 84 out of 108 manufacturers of cough syrups in the state.
Four of them were directed to stop production while the licences of six companies were suspended, he said.
As many as 17 firms were served show-cause notices for violation of rules, the minister added.
Shelar referred to the deaths of 66 children in Gambia allegedly because of cough syrups imported from India.
But the minister said that the company which was facing the charge of violation of rules in that case was based in Haryana and had no manufacturing unit in Maharashtra.
“We have, however, taken a strict action against the violators of rules. We are ensuring that the World Health Organization’s GMP (good manufacturing practises) certification-related rules and Certificate of Pharmaceutical Products are complied with while exporting products (from the state),” he added.
Presiding officer Sanjay Shirsat said if 20 per cent of manufacturers faced raids because of suspected violation of rules, it needs to be taken very seriously as it was akin to playing with people’s lives.
Rathod said of 996 allopathic drug manufacturers in the state, 514 manufacturers export their products.
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