The News Caravan

Tag: district kupwara

  • Kashmir’s AIIMS Scientist Leads Major Cancer Breakthrough

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    by Faiqa Masoodi

    SRINAGAR: In a major breakthrough, a Kashmiri scientist along with a group of European scientists has discovered a new potential drug for the treatment of metastatic hypoxic cancers. The drug is currently in an advanced stage of further investigations post-animal trials.

    Dr Musadir Nabi Peerzada
    Dr Musadir Nabi Peerzada (AIIMS)

    Hailing from Muqami Shahwali in Kupwara’s Drugmulla belt, Dr Mudasir Nabi Peerzada led a team of eminent European scientists and co-workers to discover a new drug for the treatment of various metastatic hypoxic cancers.

    Dr Peerzada who is currently working as a C-Level scientist at AIIMS New Delhi, has completed his postdoctoral training at the National Institute of Pathology. He was awarded a prestigious postdoctoral fellowship by the Indian Council of Medical Research (ICMR), Department of health research, Government of India.

    The discovery is believed to help in silencing the HIF-1 factor-controlled human CAIX and CAXII activity in cancerous cells. The hCAIX and hCAXII are overexpressed in the renal, pancreatic, gut, oral, brain, lung, and ovarian cancers, therefore the drug could be significant in treating multiple cancers with greater efficacy.

    Dr Mudasir said that he and his team strenuous efforts for many years to make this path-breaking discovery. The drug has shown satisfactory results in various tumour models and is currently undergoing advanced investigations.

    “This discovery took us years of tests and trials. We tested it on animals before going ahead,” Dr Peerzada said, adding that the drug is undergoing advanced clinical trials for further investigation.

    The study was published in ACS Medicinal Chemistry Letters entitled Discovery of Novel Hydroxyimine-Tethered Benzenesulfonamides as Potential Human Carbonic Anhydrase IX/XII Inhibitors was published on May 8, 2023.

    He said that the new findings are remarkable in curing hypoxic cancers and will be a boon for cancer-related research.

    The other scientists who are part of this invention include Dr Alessandro Bonardi, Dr Niccolò Paoletti, Dr Daniela Vullo, Dr Paola Gratteri, Dr Claudiu T Supuran, and Dr Amir Azam

    Dr Peerzada is working on the development of anti-cancer therapeutics discovery taking into account the ATP binding site of kinases, hCAIX, hCAXII activity, cycle arrest at the G2/M phase of mitosis, prevention of HER2 dimerisation to deregulate PI3K/AKT and MAPK cell signalling pathways.

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    #Kashmirs #AIIMS #Scientist #Leads #Major #Cancer #Breakthrough

    ( With inputs from : kashmirlife.net )

  • Avalanche Alert In Two Districts Of Kashmir

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    SRINAGAR: Jammu and Kashmir Disaster Management Authority (JKDMA) on Wednesday issued an avalanche warning over higher reaches in two districts of Kashmir division.

    Quoting officials, news agency GNS reported that a ‘low’ danger level avalanche is likely to occur 2600 metres above sea level in Kupwara district in next 24 hours.

    Also, an avalanche of a ‘medium’ danger leveL 2500 metres above sea level is likely to occur in Bandipora district.

    People living in these areas have been advised to take precautions and avoid venturing in the avalanche prone areas till further orders.

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    #Avalanche #Alert #Districts #Kashmir

    ( With inputs from : kashmirlife.net )

  • Court Rejects Bail To Five Solders Arrested In Drug Peddling

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    SRINAGAR: A Kashmir court has turned down the bail application of five soldiers who were arrested in a drug peddling case, NDTV reported. The court ruled that their detention is required to lay hands on other accused.

    The five soldiers were operating the drug-peddling gang while being posted at Panzgam in Kupwara. They were arrested last month and accused for running the drug cartel from Tangdhar, a border town located on the Line of Control (LoC).

    The bail application was moved before the Additional district and sessions judge, Kupwara, who rejected the plea. The court observed that soldiers were supposed to protect society but regretted this bunch worked in contravention of it.

    “According to the police, drugs were coming from Pakistan through Tangdhar sector and five soldiers posted in Panzgam area of Kupwara were involved in drug trafficking,” the NDTV report said, identifying the accused soldiers as Naib-Subedar Puran Singh, Anil Kumar (driver) Sepoy Sushil Kumar, Naik Waseem Ahmad Mir and Mohammad Shafiq Khan.

    The soldiers apparently were working with four civilians who were identified as Mashkoor Sheikh (working as a porter with Army), Mohammad Yousaf Kothari, Saleem Sheikh and Mohammad Imran Teli.

    This is the second time in the last two months that security personnel have been arrested for drug smuggling from the Line of Control in Kupwara district.

    The report said that federal investigator, NIA arrested a BSF officer posted in Handwara – also part of the frontier Kupwara district, “on charges of cross-border drug smuggling linked with the Lashkar-e-Toiba terrorist group”. Identified as Romesh Kumar, report said Rs 91 lakh cash was recovered from Kumar.

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    #Court #Rejects #Bail #Solders #Arrested #Drug #Peddling

    ( With inputs from : kashmirlife.net )