Tag: breakthrough

  • Kashmir’s AIIMS Scientist Leads Major Cancer Breakthrough

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    by Faiqa Masoodi

    SRINAGAR: In a major breakthrough, a Kashmiri scientist along with a group of European scientists has discovered a new potential drug for the treatment of metastatic hypoxic cancers. The drug is currently in an advanced stage of further investigations post-animal trials.

    Dr Musadir Nabi Peerzada
    Dr Musadir Nabi Peerzada (AIIMS)

    Hailing from Muqami Shahwali in Kupwara’s Drugmulla belt, Dr Mudasir Nabi Peerzada led a team of eminent European scientists and co-workers to discover a new drug for the treatment of various metastatic hypoxic cancers.

    Dr Peerzada who is currently working as a C-Level scientist at AIIMS New Delhi, has completed his postdoctoral training at the National Institute of Pathology. He was awarded a prestigious postdoctoral fellowship by the Indian Council of Medical Research (ICMR), Department of health research, Government of India.

    The discovery is believed to help in silencing the HIF-1 factor-controlled human CAIX and CAXII activity in cancerous cells. The hCAIX and hCAXII are overexpressed in the renal, pancreatic, gut, oral, brain, lung, and ovarian cancers, therefore the drug could be significant in treating multiple cancers with greater efficacy.

    Dr Mudasir said that he and his team strenuous efforts for many years to make this path-breaking discovery. The drug has shown satisfactory results in various tumour models and is currently undergoing advanced investigations.

    “This discovery took us years of tests and trials. We tested it on animals before going ahead,” Dr Peerzada said, adding that the drug is undergoing advanced clinical trials for further investigation.

    The study was published in ACS Medicinal Chemistry Letters entitled Discovery of Novel Hydroxyimine-Tethered Benzenesulfonamides as Potential Human Carbonic Anhydrase IX/XII Inhibitors was published on May 8, 2023.

    He said that the new findings are remarkable in curing hypoxic cancers and will be a boon for cancer-related research.

    The other scientists who are part of this invention include Dr Alessandro Bonardi, Dr Niccolò Paoletti, Dr Daniela Vullo, Dr Paola Gratteri, Dr Claudiu T Supuran, and Dr Amir Azam

    Dr Peerzada is working on the development of anti-cancer therapeutics discovery taking into account the ATP binding site of kinases, hCAIX, hCAXII activity, cycle arrest at the G2/M phase of mitosis, prevention of HER2 dimerisation to deregulate PI3K/AKT and MAPK cell signalling pathways.

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    #Kashmirs #AIIMS #Scientist #Leads #Major #Cancer #Breakthrough

    ( With inputs from : kashmirlife.net )

  • Doha: No breakthrough in sight as India joins UN to resolve Afghan issue

    Doha: No breakthrough in sight as India joins UN to resolve Afghan issue

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    New Delhi: India participated in a two-day closed-door conference on Afghanistan with 20 other countries led by UN Secretary-General Antonio Guterres to discuss the Afghan crisis. The UN was spurred by the deteriorating situation in the landlocked nation to organise the meeting along with the US, Russia, China and other nations.

    The UN said that the aim of the meet was to “reinvigorate international engagement around key issues, such as human rights, in particular women’s and girls’ rights, inclusive governance, countering terrorism and drug trafficking. The meeting is intended to achieve a common understanding within the international community on how to engage with the Taliban on these issues”.

    The Doha meeting, however, came under criticism from both – the Taliban and also Afghan women for not inviting them both for the discussions.

    MS Education Academy

    Suhail Shaheen, the spokesperson for the Taliban said that any meeting without the Islamic Emirate of Afghanistan (IEA) was discriminatory and unjustified as the Taliban government was the main party.

    However, it emerged from Doha that Afghan Foreign Minister Amir Khan Muttaqi, who has been banned from travel, will be visiting Pakistani capital Islamabad to hold talks with Pakistani and Chinese foreign ministry officials.

    Women’s groups have held protests in Doha, for what they claimed were efforts by the UN to legitimise the Taliban regime despite the throttling of women’s rights in the country. The Taliban, contrary to assurances, after storming back to power in 2021 began steadily curtailing the rights of girls and women to education, stepping out of homes, visiting a doctor, marriage and divorce as well as working for UN agencies. The last one, which was imposed recently, galvanised women’s groups across the world against the Taliban rule.

    Afghanistan’s Khaama news agency quoted Swiss ambassador to the UN, Pascale Baeriswyl, as saying that the situation in Afghanistan under the Taliban administration has turned into a complicated dilemma. “We do not have a magic solution to the Afghan crisis”, Baeriswyl said, adding that she is hopeful that the Doha meeting would lead to solutions to managing the Afghan crisis. Switzerland is currently the president of the UN Security Council (UNSC).

    The people of Afghanistan continue to face hardships due to the unending conflict, droughts and economic problems, though the Taliban has $7 billion worth of sophisticated US weaponry which the American troops left behind in 2021 after 20 years of the war against terror.

    (The content is being carried under an arrangement with indianarrative.com)

    –indianarrative

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    #Doha #breakthrough #sight #India #joins #resolve #Afghan #issue

    ( With inputs from www.siasat.com )

  • House GOP leaves Washington with a debt win — but not quite a breakthrough

    House GOP leaves Washington with a debt win — but not quite a breakthrough

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    congress debt 00962

    While Republicans believed the plan they passed Wednesday would force Biden to the table, the White House and most congressional Democrats have brushed it off and made clear they won’t entertain the GOP’s demands. Instead, both sides have retreated further into their corners, with each party planning to spend the coming days talking almost entirely to its respective base voters.

    “I think we in the House ought to message the hell out of it,” Rep. Chip Roy (R-Texas) said, warning that Democrats would “make false claims” about their bill: “We need to be on offense on the message.”

    As for the next steps, Roy said: “The ball’s in the president’s court and the Senate court.”

    Roy is far from alone in the GOP conference in arguing that the problem is no longer in their hands, putting the blame squarely on Democrats’ shoulders. Most Republican lawmakers insist they have little anxiety about the increasingly rattled nerves on Wall Street as a dysfunctional Congress barrels closer toward this summer’s drop-dead debt limit date.

    “Every day that he refuses to negotiate, he is putting the U.S. economy at risk,” Rep. Mario Diaz-Balart (R-Fla.) said. “The next move is on Biden.”

    Top Democrats have revealed little about their next steps. While Senate Majority Leader Chuck Schumer (D-N.Y.) has called on Republicans to work with him on a clean debt plan, it’s unclear if his caucus would even unite to vote in favor of one. Sen. Joe Manchin (D-W.Va.), specifically, has put the onus on Biden to meet with McCarthy.

    And at least some in the party are getting nervous: “We all should be getting anxious,” Rep. Elissa Slotkin (D-Mich.) said.

    All the focus next week will be on the Senate, which will return to Washington facing the pressure from House Republicans — and possibly from the Treasury Department. Officials there are expected sometime in the coming days to update the public on the “X date,” before which Congress will need to pass a debt limit lift to avoid default.

    “I think once we have that date with clarity … then we’ll know with some urgency our timeframe for dealing with this challenge,” House Minority Leader Hakeem Jeffries (D-N.Y.) told reporters Friday, adding: “Understand that this is a manufactured crisis that extreme MAGA Republicans are foisting on the American people.”

    In the meantime, Democrats plan to spend their time turning the GOP’s debt plan into campaign fodder, betting that fresh attacks on Republican plans to slash spending on programs like food stamps and Medicaid will hurt in the swing districts they need to flip next November.

    Many of the Republicans currently holding those battleground seats, however, say they aren’t sweating their yes votes.

    Rep. Nick LaLota (R-N.Y.), who flipped a purple Long Island seat last fall, said he recently did a tele-town hall with over 13,000 callers where he asked each person to weigh in on whether they supported his position on debt: Raising the limit, but with some cutbacks to federal spending, including Covid aid.

    “Three to one, [constituents] agreed with my position,” LaLota said Friday.

    Ever since House Republicans passed its plan on Wednesday, both parties have resorted to finger-pointing to try to pin blame if negotiations go south.

    Still, the GOP bill remains a win for McCarthy, who faced a steep climb as he wrangled a deal among the disparate wings of his party with only a handful of votes to spare. By working closely with conservatives to craft a plan packed with right-flank priorities, the speaker achieved near-total unity in his bid to kick off negotiations with Biden.

    Even so, White House officials have emphasized in conversations with Democratic congressional leaders the importance of staying aligned on Biden’s no-negotiation stance. The president’s team is clearly betting that it still holds the stronger hand in the debt ceiling standoff; the White House reacted to the House GOP’s bill by issuing a flurry of statements and analyses detailing the damage it would do to the economy and popular programs.

    While Biden administration officials have explored a variety of potential alternative options for averting default, there is skepticism that any would be workable — and none are seen as preferable to Congress simply voting to raise the debt ceiling.

    The House Republican pitch that would raise the debt limit by $1.5 trillion, or through March of next year — whichever comes first — setting up another fight with the White House next year. In particular, Republicans are proudest of the bill’s slashes to federal spending, including $130 billion in the upcoming fiscal year that would effectively return discretionary spending totals to nearly the same level as two years ago.

    But the task is far from done, and McCarthy still could be squeezed yet by his own party.

    Some members of the conservative Freedom Caucus are arguing that the California Republican should refuse to negotiate down at all as Democrats decide on their counter — a position that other Republicans in the conference view as irrational.

    “I don’t do red lines because there might be a different price that I might want for something, right? Put a border bill on there, change the length and times. There’s always a way to come up with something that will actually be good for the country,” Roy said of the potentially negotiable items.

    “Go ahead, Mr. President,” he added. “Go ahead, Sen. Schumer.”

    Adam Cancryn and Nicholas Wu contributed to this report.

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    #House #GOP #leaves #Washington #debt #win #breakthrough
    ( With inputs from : www.politico.com )

  • ‘Decisive breakthrough’: UK PM Rishi Sunak declares new Brexit pact

    ‘Decisive breakthrough’: UK PM Rishi Sunak declares new Brexit pact

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    London: British Prime Minister Rishi Sunak on Monday unveiled a “decisive breakthrough” in achieving a new deal with the European Union (EU) to resolve the post-Brexit trade dispute related to Northern Ireland.

    After weeks of intensive negotiations, Sunak was joined by European Commission President Ursula von der Leyen for a final set of in-person talks in Windsor, south east England, after which the duo addressed the media to confirm a new “Windsor Framework”.

    It replaces the previous Northern Ireland Protocol, agreed by Sunak’s former boss Boris Johnson to prevent a hard border between UK territory Northern Ireland and EU member-state Ireland but eventually proving unworkable and causing much tension between the UK and EU.

    “I’m pleased to report that we have now made a decisive breakthrough. Together we have changed the original protocol and are today announcing the new Windsor framework,” Sunak told reporters.

    “Today’s agreement delivers smooth-flowing trade within the whole United Kingdom, protects Northern Ireland’s place in our union and safeguards sovereignty for the people of Northern Ireland and [removes] any sense of a border in the Irish Sea,” he said.

    Von der Leyen echoed Sunak’s optimism to say that the UK and EU can now open a new chapter in their post-Brexit relationship.

    They detailed “big steps forward” to deliver trade flow with goods destined for Northern Ireland travelling through a new “green lane” with a separate “red lane” reserved for items expected to move on to the EU.

    “We will end the situation where food made to UK rules could not be sent to and sold in Northern Ireland. This means that if food is available on supermarket shelves in Great Britain, then it will be available on supermarket in Northern Ireland,” said Sunak.

    The legal text of the Northern Ireland Protocol has been amended to ensure critical VAT and excise changes for the whole of the UK can be made and the devolved Northern

    Irish parliament in Stormont would have a say on the changes. “These negotiations have not always been easy, but I’d like to pay an enormous personal tribute to Ursula for her vision in recognising the possibility of a new way forward… Today’s agreement is about preserving that delicate balance and charting a new way forward for the people of Northern Ireland,” added Sunak.

    The British Indian leader now faces the uphill task of getting Northern Ireland’s Democratic Unionist Party (DUP) on board with the new Windsor Framework.

    The DUP had been strongly opposed to the earlier protocol, which meant goods arriving from England, Scotland and Wales within the United Kingdom were checked when they arrived at Northern Irish ports. This was seen as undermining the region’s position within the rest of the UK, besides severely impacting trade.

    The other group likely to make things difficult for Sunak in the House of Commons include the hard Brexiteers within the Conservative Party, including backbencher Johnson, who had warned against backing down over Northern Ireland Protocol Bill which would have given the UK Parliament a chance to unilaterally change parts of the protocol.

    However, Sunak had indicated that a fresh negotiated agreement with the EU was preferable over the controversial Bill that would have put the UK on a legal collision course with its European neighbours.

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    #Decisive #breakthrough #Rishi #Sunak #declares #Brexit #pact

    ( With inputs from www.siasat.com )